It's hard to believe that there hasn't been an MLB All-Star from the University of Cincinnati since Kevin Youkilis (Correction: Josh Harrison in 2014). The homegrown talent from Sycamore high school dominated for the Bearcats back in 2001 where he hit .405 with 18 home runs and 61 RBI's. Despite Youkilis's numbers in college, he was still only drafted in the 8th round of the 2001 draft because scouts said that he had a "defected" swing.
Clearly as each team passed on Youkilis round by round, he took it to heart proving scouts wrong as he finished his 10-year career with a .281 batting average, 150 home runs, a World Series ring and 3 All-Star game appearances. His best season came in 2008 when he finished 3rd in the American League MVP voting, posting an impressive .312 batting average with 115 RBI's.
The Bearcats most notable player recently has been 20-year old center fielder Ian Happ who was drafted in the first round of 2015 MLB draft by the Chicago Cubs. Happ has all the potential in the world but only time will tell who the next Bearcat All-Star will be.
EDIT: Cincinnati's own Josh Harrison was the last to be selected to the MLB All-Star Game in 2014, representing the Pittsburgh Pirates (thank you thebig3c). Harrison finished his 2014 campaign batting .315 with 13 home runs, 164 hits and 52 RBI's. He also added 18 stolen bases and some great defensive plays. In the video below, you will find Harrison's impressive first-half to the 2014 season including some incredibly entertaining base running around the 1:30 mark.